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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Cells of the Epidermis01:24

Cells of the Epidermis

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Related Experiment Video

Updated: Mar 16, 2026

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
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SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

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648

Basal cell carcinoma in psoriasis.

F Powell1, J P Mackey1

  • 1Department of Dermatology, Mater Misericordiae Hospital, Eccles Street, Dublin 7.

Irish Journal of Medical Science
|August 13, 2016
PubMed
Summary

Psoriasis patients treated with tar, dithranol, and clobetasol propionate developed basal cell carcinoma within a plaque. This case highlights the importance of monitoring skin malignancy risk in psoriasis patients undergoing topical therapy.

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Topical treatments are common for psoriasis management.
  • Potential links between psoriasis treatments and secondary malignancies warrant investigation.

Purpose of the Study:

  • To report a case of basal cell carcinoma (BCC) arising in a psoriatic plaque.
  • To discuss the incidence of skin malignancy in patients with psoriasis.

Main Methods:

  • Case report detailing the development of BCC in a psoriatic plaque.
  • Review of literature concerning skin cancer risk in psoriasis patients.

Main Results:

  • A patient with psoriasis developed basal cell carcinoma within a treated plaque.

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  • The BCC occurred after localized treatment with tar, dithranol, and clobetasol propionate.

    • Conclusions:

    • The use of topical therapies, including tar, dithranol, and clobetasol propionate, may be associated with an increased risk of secondary skin malignancies in psoriatic lesions.
    • Further research is needed to elucidate the precise relationship between psoriasis treatments and the incidence of skin cancer.