Related Experiment Video
Updated: Mar 16, 2026
08:09
Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation
Published on: October 15, 2019
7.1K
A Versatile Axle for the Construction of Disassemblage Rotaxanes.
Lucas A Powers1, David B Smithrud2
1Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA. powersla@mail.uc.edu.
Molecules (Basel, Switzerland)
|August 13, 2016
Summary
Two new rotaxanes with acid/base sensitive triggers were developed for sensing applications. These rotaxanes readily disassemble in various environments, showing promise for sensor development.
Area of Science:
- Supramolecular Chemistry
- Chemical Sensing
Background:
- Rotaxanes are mechanically interlocked molecules with potential applications in molecular devices.
- Developing stimuli-responsive rotaxanes is crucial for advanced sensor technology.
Purpose of the Study:
- To synthesize and characterize novel rotaxanes featuring acid or base sensitive triggers.
- To evaluate the disassembly properties of these rotaxanes in aqueous environments.
- To demonstrate the potential for derivatization and rapid sensor development.
Main Methods:
- Synthesis of two new rotaxane structures with acid/base sensitive triggers.
- Disassembly analysis using Thin-Layer Chromatography (TLC).
- Structural confirmation and disassembly monitoring via proton Nuclear Magnetic Resonance (¹H-NMR) spectroscopy.
- Evaluation of axle charge for aqueous solubility and derivatization potential.
Main Results:
- Successful synthesis of rotaxanes with acid/base sensitive triggers.
- Observed facile disassembly of rotaxanes in various environments, confirmed by TLC and ¹H-NMR.
- The highly charged axle facilitated enhanced solubility in aqueous media.
- Demonstrated potential for easy derivatization of the axle with sensor components.
Conclusions:
- The developed rotaxanes are promising candidates for sensor applications due to their stimuli-responsive disassembly.
- The facile synthesis and derivatization capabilities offer a pathway for rapid development of diverse sensor arrays.
- High aqueous solubility broadens the applicability of these rotaxanes in biological and environmental sensing.
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Related Concept Videos
02:02Chair Conformation of Cyclohexane
20.6K
The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
20.6K
01:23Pivot Bearings
2.4K
In mechanical systems, bearings are crucial in facilitating relative motion between two components while minimizing friction and wear. They help distribute various loads (radial, axial or a combination of both loads) across machinery parts, ensuring smooth and efficient operation.
A pivot bearing is a specialized type of bearing designed to support axial loads on a rotating shaft. The bearing surface, or the pivot, is positioned at the end of a shaft to support the axial thrust. The pivot may...
A pivot bearing is a specialized type of bearing designed to support axial loads on a rotating shaft. The bearing surface, or the pivot, is positioned at the end of a shaft to support the axial thrust. The pivot may...
2.4K
![[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2Ffiles%2Fmedia%2Fscience-education%2Fscience-education-thumbs%2F12417.jpg&w=3840&q=75)
01:16[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
13.6K
The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
13.6K
02:50Spindle Assembly
4.4K
Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
4.4K
02:50Spindle Assembly
2.2K
2.2K
02:11Conformations of Cyclohexane
16.8K
Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
16.8K