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The significance of Warburg's work for the transformation of concepts in the investigation of vitamins is stressed, and the different investigative approaches of the competing groups are made clear. The grounds for the controversy carried out in their scientific publications, between Paul Karrer and Warburg on the one side, and Richard Kuhn on the other side, are fully examined, using the example of vitamin B2.A second level of discussion that remained hidden from behind the public scientific debate is analysed: the prioriy dispute between the savants was connected with the interests of the chemical industry.