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[Karyotype-phenotype correlation in a child with an idic (Yp)]
Boletin Medico Del Hospital Infantil De Mexico
|June 1, 1989
Summary
This study describes an 8-year-old boy with hypospadias and a rare isodicentric Y chromosome (idic(Yp)). Phenotypic variability in such cases may stem from differing cell populations, with Yq deletion distal to growth factors.
Area of Science:
- Genetics and Molecular Biology
- Pediatric Endocrinology
- Developmental Biology
Background:
- Hypospadias is a congenital condition affecting male urinary tract development.
- Isodicentric Y chromosome (idic(Yp)) is a rare chromosomal abnormality characterized by a duplicated Y chromosome.
- Mosaicism, the presence of two or more cell lines with different genotypes, can occur in chromosomal abnormalities.