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Updated: Mar 16, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Bile Acid Analog Intercepts Liver Fibrosis

C Daniel De Magalhaes Filho1, Michael Downes1, Ron Evans1

  • 1Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Cell
|August 13, 2016
PubMed
Summary

Ocaliva, a synthetic bile acid analog, effectively treats primary biliary cholangitis in patients unresponsive to ursodeoxycholic acid (UDCA). This FXR agonist offers an alternative for autoimmune liver disease management.

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