Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Karyotyping01:17

Karyotyping

69.7K
Overview
69.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial differences in the ovine cervical microenvironment at the follicular and luteal phases of the oestrous cycle; Implications for sperm transport.

Theriogenology·2026
Same author

What are the experiences of supportive care in people affected by brain cancer and their informal caregivers: A qualitative systematic review.

Journal of cancer survivorship : research and practice·2023
Same author

Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.

The European physical journal. C, Particles and fields·2022
Same author

Canadian Surgery Forum.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Adherence to Canada's Food Guide recommendations among Alberta's multi-ethnic youths is a major concern: findings from the WHY ACT NOW project.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2018
Same author

Sex differences in cardiovascular disease - Impact on care and outcomes.

Frontiers in neuroendocrinology·2017

Related Experiment Video

Updated: Mar 16, 2026

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

1.1K

Quantitative nitroblue tetrazolium test in mongolism.

N Johnston1,2, J B Bridges1,2, N C Nevin1,2

  • 1The Department of Haematology, Royal Belfast Hospital for Sick Children, Belfast, UK.

Irish Journal of Medical Science
|August 13, 2016
PubMed
Summary

Leukocyte function in individuals with Down syndrome (mongols) was assessed. Elevated erythrocyte sedimentation rates (ESRs) were linked to distinct NBT test results, suggesting ESR levels are crucial for future studies.

More Related Videos

Novel Whole-tissue Quantitative Assay of Nitric Oxide Levels in Drosophila Neuroinflammatory Response
07:49

Novel Whole-tissue Quantitative Assay of Nitric Oxide Levels in Drosophila Neuroinflammatory Response

Published on: December 4, 2013

8.3K
A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
07:38

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

Published on: September 25, 2017

10.8K

Related Experiment Videos

Last Updated: Mar 16, 2026

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

1.1K
Novel Whole-tissue Quantitative Assay of Nitric Oxide Levels in Drosophila Neuroinflammatory Response
07:49

Novel Whole-tissue Quantitative Assay of Nitric Oxide Levels in Drosophila Neuroinflammatory Response

Published on: December 4, 2013

8.3K
A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
07:38

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

Published on: September 25, 2017

10.8K

Area of Science:

  • Immunology
  • Genetics
  • Hematology

Background:

  • Leukocyte function is critical for immune response.
  • Down syndrome (mongolism) is associated with immune system alterations.
  • Erythrocyte sedimentation rate (ESR) is a non-specific marker of inflammation.

Purpose of the Study:

  • To assess leukocyte function in individuals with Down syndrome.
  • To investigate the relationship between ESR levels and leukocyte function.
  • To determine if ESR influences NBT test results in this population.

Main Methods:

  • Quantitative nitroblue tetrazolium (NBT) test was employed.
  • White cell counts were performed.
  • Erythrocyte sedimentation rates (ESRs) were measured.

Main Results:

  • Out of 28 individuals with Down syndrome, eight exhibited elevated ESRs.
  • The NBT test results differed significantly between individuals with normal and elevated ESRs.
  • A correlation was observed between ESR levels and specific leukocyte function parameters.

Conclusions:

  • Leukocyte function in individuals with Down syndrome is influenced by ESR levels.
  • Future research on leukocyte function in Down syndrome must consider ESR as a confounding factor.
  • ESR may serve as an indicator for specific immune responses in individuals with Down syndrome.