Related Experiment Video
Updated: Mar 16, 2026

Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional 3D Model
Published on: June 11, 2014
STAT3-induced WDR1 overexpression promotes breast cancer cell migration
Joo Hyun Lee1, Ji Eun Kim1, Baek Gil Kim2
1Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Republic of Korea; Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Abstract:
WD repeat domain 1 (WDR1), a protein that assists cofilin-mediated actin filament disassembly, is overexpressed in the invading front of invasive ductal carcinoma (IDC), but its implication of overexpression and how to be regulated have not been studied. In our study, we demonstrated that STAT3 bound to the 5' upstream sequence (-1971 to -1964), a putative promoter region, of WDR1 gene, and its activation induced WDR1 overexpression in breast cancer cells. The exogenous overexpression of WDR1 increased the migration of MDA-MB-231, which was attenuated by WDR1 knockdown. In the analysis of breast cancer patients, WDR1 overexpression was associated with a shorter distant metastasis-free survival (DMFS), more specifically in basal-like tumors.
More Related Videos
Related Concept Videos
Cancer Cell Migration through Invadopodia
Canonical Wnt Signaling Pathway
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
Abnormal Proliferation

