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High-dose IgG treatment for neonatal alloimmune thrombocytopenia
C Mueller-Eckhardt1, V Kiefel, A Grubert
1Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Federal Republic of Germany.
Abstract:
Twelve children with neonatal alloimmune thrombocytopenia (NAT) due to Zwa incompatibility were treated with intravenous IgG (IVIG). Total doses ranged between 1 and 9 g. Ten out of 12 infants had a favorable response. It is concluded that IVIG can serve as an emergency treatment in NAT if material (or compatible) platelets are not available.