Kidney activity increases in copper exposed goldfish (Carassius auratus auratus)

In the present study, the effect of copper was examined in the common goldfish (Carassius auratus auratus). Fish were fasted and exposed to either a high (0.84μM), a low (0.34μM) or a control copper concentration (0.05μM) for 1 and 7days. Swimming performance was not affected by either fasting or copper exposure. Food deprivation alone had no effect on ionoregulation, but low plasma osmolality levels and plasma Na⁺ were noticed in fasted fish exposed to Cu for 7days. Both gill Na⁺/K⁺-ATPase and H⁺-ATPase activities were undisturbed, while both kidney ATPase activities were up-regulated when challenged with the high Cu levels. Up-regulated kidney ATPase activities likely acted as compensatory strategy to enhance Na⁺ reabsorption. However, this up-regulation was not sufficient to restore Na⁺ to control levels in the highest exposure group.