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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Survival and toxicity after breast-conserving surgery and external beam reirradiation for localized ipsilateral breast tumour recurrence: A population-based study.

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Late hepatic toxicity after breast cancer intensity-modulated radiotherapy using helicoidal tomotherapy.

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[Radiotherapy and targeted therapy for the management of breast cancer: A review].

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Long-term efficacy and tolerance of a technique for postmastectomy electron beam radiation therapy of the unreconstructed chest wall and lymph node areas for non-metastatic breast cancers.

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[Radiotherapy of breast cancer].

C Hennequin1, I Barillot2, D Azria3

  • 1Service de cancérologie-radiothérapie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75475 Paris, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|August 15, 2016
PubMed
Summary

Radiotherapy is crucial for breast cancer treatment, reducing recurrence after surgery. Specific guidelines exist for different stages and procedures, including chest wall, axillary, and nodal irradiation, with dose and fractionation considerations.

Keywords:
Breast cancerCancer du seinPractical guidelinesRadiotherapyRadiothérapieRecommandations pratiques

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Breast Cancer Treatment

Background:

  • Radiotherapy is a cornerstone in breast cancer management, significantly impacting local recurrence rates and survival.
  • Established protocols guide its application after various surgical procedures, including conservative surgery and mastectomy.
  • The abstract outlines current recommendations for adjuvant and post-mastectomy radiotherapy based on tumor characteristics and nodal status.

Purpose of the Study:

  • To provide a comprehensive overview of radiotherapy indications and techniques in breast cancer management.
  • To detail specific recommendations for different clinical scenarios, including conservative surgery, mastectomy, and in situ disease.
  • To discuss dose fractionation, target delineation, and advanced techniques like intensity-modulated radiotherapy and respiratory gating.

Main Methods:

  • Review of current clinical guidelines and evidence for radiotherapy in breast cancer.
  • Analysis of indications for chest wall, breast, axillary, and nodal irradiation based on tumor stage and surgical history.
  • Discussion of dose prescription, fractionation schedules (conventional and hypofractionation), and treatment planning techniques.

Main Results:

  • Systematic radiotherapy is recommended after conservative surgery for infiltrating carcinoma and lumpectomy for ductal carcinoma in situ.
  • Chest wall irradiation is indicated after mastectomy for specific tumor sizes (pT3-T4) and nodal involvement.
  • Dose recommendations range from 45-50Gy with conventional fractionation, with boost doses for younger patients and hypofractionation options.

Conclusions:

  • Radiotherapy plays a vital role in improving outcomes for breast cancer patients.
  • Adherence to specific irradiation guidelines based on disease characteristics and treatment context is essential.
  • Technological advancements and careful dose/fractionation planning can optimize treatment efficacy and minimize toxicity.