Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Noninvasive oximetry in the rat.

M J Decker1, K P Conrad, K P Strohl

  • 1Department of Medicine, Case Western Reserve University, Cleveland, Ohio.

Biomedical Instrumentation & Technology
|May 1, 1989
PubMed
Summary

Noninvasive pulse oximetry (SpO2) effectively monitors oxygen saturation (SaO2) trends in rats. Accuracy is acceptable between 75%-95% SaO2 for developing respiratory dysfunction models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ventilatory and heart rate responses to hypoxia in pre- and post-menopausal ethnically Tibetan women residing at ∼3800 m in Mustang, Nepal.

The Journal of physiology·2026
Same author

Restoration of Sleep Architecture after Maxillomandibular Advancement: Success Beyond the Apnea-Hypopnea Index.

International journal of oral and maxillofacial surgery·2017
Same author

Respiratory and hematological adaptations of young and older Aymara men native to 3600M.

American journal of human biology : the official journal of the Human Biology Council·2017
Same author

Vascular actions of relaxin: nitric oxide and beyond.

British journal of pharmacology·2016
Same author

Right ventricle dimensions and function in response to acute hypoxia in healthy human subjects.

Acta physiologica (Oxford, England)·2016
Same author

Scn1a dysfunction alters behavior but not the effect of stress on seizure response.

Genes, brain, and behavior·2015

Area of Science:

  • Physiology
  • Medical Devices
  • Animal Models

Background:

  • Developing rodent models for respiratory dysfunction requires reliable monitoring tools.
  • Noninvasive methods for assessing oxygen saturation are crucial for animal research.

Purpose of the Study:

  • To evaluate the efficacy of noninvasive pulse oximetry (SpO2) for continuous monitoring of arterial oxygen saturation (SaO2) in rats.
  • To determine the accuracy of pulse oximetry compared to blood gas analysis in rodent models.

Main Methods:

  • Utilized a Nellcor N-100 pulse oximeter with a tail-placed sensor in rats.
  • Induce hypoxia using hypobaric decompression and varying fractions of inspired oxygen (FIO2).
  • Collected arterial blood samples for SaO2 analysis using an IL 282 CO-Oximeter and compared with pulse oximeter readings.

Main Results:

  • Pulse oximetry detected decreases in SaO2 during induced hypoxia.
  • Between 75% and 95% SaO2, the standard deviation for pulse oximetry vs. CO-Oximeter was +/-5.7%.
  • Below 70% SaO2, pulse oximeter readings were higher than arterial values with increased variability.

Conclusions:

  • Pulse oximetry is a viable tool for monitoring oxygenation trends in rats, both anesthetized and unanesthetized.
  • The accuracy of pulse oximetry is acceptable for SaO2 values between 75% and 95% in this model.
  • This technique aids in the development of rodent models for studying respiratory dysfunction.

Related Experiment Videos