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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
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Delivery of CD151 by Ultrasound Microbubbles in Rabbit Myocardial Infarction
Shao-Ling Yang1, Ke-Qiang Tang, Jun-Jia Tao
1Ultrasound in Medicine Departments, Shanghai Fengxian Central Hospital/Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai, China.
Objectives:
We aimed to evaluate whether ultrasound (US) and microbubble-mediated delivery of Cluster of Differentiation 151 (CD151) could enhance the therapeutic effects of CD151 on myocardial infarction (MI).
Methods:
A rabbit model of MI was established by a modified Fujita method. Then, 50 MI rabbits were randomly divided into 5 groups, including G1 (CD151 plasmid and physiological saline in the presence of US); G2 (CD151 and Sonovue in the presence of US); G3 (CD151 and Sonovue in the absence of US); G4 (Sonovue in the absence of US), and a control group (physiological saline in the absence of US). After 14 days of treatment, the expression of CD151 was detected by Western blot. Besides, vessel density of peri-infarcted myocardium was measured by immunohistochemistry, and cardiac function was analyzed by echocardiography.
Results:
The rabbit model of MI was established successfully. CD151 injection increased the expression of CD151 and microvessel density in the myocardium of MI rabbits. Heart function was significantly improved by CD151, which exhibited increased left ventricular ejection fraction, left ventricular fractional shortening and a reduced Tei index. Besides, US Sonovue significantly increased the expression efficiency of CD151.
Conclusion:
US microbubble was an effective vector for CD151 delivery. CD151 might be an effective therapeutic target for MI.
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