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[INSULIN RESISTANCE ASSOCIATED WITH METABOLIC SYNDROME AS AN INDICATOR OF CARDIOVASCULAR RISK]

A V Dontsov, L V Vasil'eva

    Klinicheskaia Meditsina
    |August 16, 2016
    PubMed

    Insights

    Metabolic syndrome significantly elevates blood insulin levels and insulin resistance in coronary heart disease (CHD) patients. This indicates increased cardiovascular risk due to associated factors like dyslipidemia and inflammation.

    Area of Science:

    • Cardiology
    • Metabolic Disorders
    • Biochemistry

    Background:

    • Coronary heart disease (CHD) poses a significant global health burden.
    • Metabolic syndrome (MS) is increasingly recognized as a major risk factor for cardiovascular diseases.
    • Understanding the interplay between MS, insulin levels, and cardiovascular risk factors in CHD patients is crucial.

    Purpose of the Study:

    • To investigate blood insulin levels in patients with CHD, comparing those with and without MS.
    • To examine the relationship between insulin levels, insulin resistance, and various cardiovascular risk factors in CHD patients.

    Main Methods:

    • A cohort of 127 stable CHD patients (63 with MS, 64 without MS) and 80 healthy controls were studied.
    • Blood insulin, glycated hemoglobin (HbA1c), lipids (total cholesterol, HDL, triglycerides), and inflammatory markers (oxidized LDL, IL-1β, IL-6, TNF-α) were measured.
    • Insulin resistance was assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index, and depression was evaluated using the Zung scale.

    Main Results:

    • CHD patients with MS exhibited significantly higher blood insulin levels (15.5 mcIE/ml) compared to those without MS (9.5 mcIE/ml) and healthy controls (6.3 mcIE/ml) (p < 0.001).
    • HOMA-IR showed a direct correlation with waist circumference, HbA1c, total cholesterol, triglycerides, oxidized LDL, IL-1β, IL-6, and TNF-α.
    • HOMA-IR demonstrated a negative correlation with HDL cholesterol levels.

    Conclusions:

    • Metabolic syndrome in CHD patients is associated with hyperinsulinemia, insulin resistance, elevated HbA1c, dyslipidemia, and increased pro-inflammatory cytokines.
    • The strong correlation between HOMA-IR and key pathogenetic factors suggests its utility as a cardiovascular risk indicator in CHD patients with MS.
    • These findings highlight the complex metabolic dysregulation in CHD patients with MS and underscore the need for comprehensive risk management.
    Abstract

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