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Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

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In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
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Factors affecting Blood pressure01:28

Factors affecting Blood pressure

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Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
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Vascular Resistance01:20

Vascular Resistance

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Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
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Pulse wave velocity and other indicators of arterial stiffness in hypertension comorbidity and chronic obstructive pulmonary disease.

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[Assessing the influence of predictors of the development of chronic obliterating diseases of lower-limb arteries].

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[The levels of osteoprotegerin, transforming growth factor-β, and some cytokines in women with coronary heart disease concurrent with severe osteoporosis].

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[ARTERIAL STIFFNESS AND BONE MINERAL DENSITY IN WOMEN WITH CORONARY HEART DISEASE AND CONCOMITANT SEVERE OSTEOPOROSIS].

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[Prognostic value of risk factors for cardiovascular diseases and target organ damages for the occurrence of resistant hypertension].

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Related Experiment Video

Updated: Mar 16, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

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[PREDICTORS OF RESISTANT ARTERIAL HYPERTENSION].

A Y Lazutkina, V V Gorbunov

    Klinicheskaia Meditsina
    |August 16, 2016
    PubMed
    Summary

    This 6-year study observed 7959 railway workers to predict resistant arterial hypertension. Findings offer insights into hypertension development and management for this occupational group.

    Area of Science:

    • Occupational Health
    • Cardiovascular Medicine
    • Epidemiology

    Context:

    • Prospective observation of 7959 locomotive crew members over 6 years.
    • Focus on the Transbaikal Railways occupational setting.
    • Investigating predictors of resistant arterial hypertension.

    Purpose:

    • To estimate the probability of developing resistant arterial hypertension.
    • To determine the time course of resistant arterial hypertension development.
    • To identify key predictors influencing hypertension onset in railway workers.

    Summary:

    • The study analyzed data from a large cohort of railway workers.
    • Key predictors for resistant arterial hypertension were identified.
    • The temporal relationship between predictors and hypertension development was examined.

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    Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats
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    Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats

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    Related Experiment Videos

    Last Updated: Mar 16, 2026

    Assessing Murine Resistance Artery Function Using Pressure Myography
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    Assessment of Vascular Function in Patients With Chronic Kidney Disease
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    Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats
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    Impact:

    • Provides valuable data for the diagnosis of resistant arterial hypertension.
    • Informs prophylactic strategies to prevent hypertension in at-risk populations.
    • Contributes to therapeutic practice for managing arterial hypertension.