Related Experiment Video
Updated: Mar 16, 2026
Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication
Published on: December 2, 2011
Amplitude of Glottal Mucosal Wave After Vocal Fold Microflap With or Without Fibrin Glue
Ramón González-Herranz1, Elizabeth Amarillo1, Estefanía Hernández-García1
1Department of Otolaryngology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain.
Introduction:
The vocal fold microflap technique is the ideal to remove benign vocal fold pathology. Our objective is to compare the amplitudes of the mucosal wave before and after the closure of microflap defect with fibrin glue, and when microflap is left to heal by secondary intention.
Materials And Methods:
The present study is a retrospective series, including 32 patients treated by intracordal phonosurgery, with closure of the microflap either with fibrin glue or by healing by secondary intention. They all had both preoperative and 6-month postoperative track records to allow voice analysis, a subjective Voice Handicap Index 10 (VHI-10), and a good image quality strobe.
Results:
After selecting the patients was found that the mean overall preoperative VHI-10 was 26.6, and improved up to 10.5 after surgery, a statistical differences (P = 0.03). When comparing both groups, with or without fibrin glue, fibrin glue did not improved results in VHI-10. On the contrary, there was a significant difference in the improvement of the open glottal phase after surgery (P = 0.03), showing a much higher improvement when fibrin glue was used.
Conclusions:
The use of fibrin glue after a vocal fold microflap for advanced pathology, such as sulcus vocalis in pocket, vergeture, or vocal fold scar, increases the amplitude of the mucosal wave of the vocal folds, but does not improve the VHI-10 results in our cohort of female patients. So far, patient-reported outcome shows that healing by secondary intention continues to provide excellent voice results.
