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Thyroxine influences neuronal connectivity in the adult frog brain
M H Hofmann1, A Michler, D L Meyer
1Department of Anatomy, School of Medicine, University of Goettingen, F.R.G.
Brain Research
|July 17, 1989
Abstract:
In contrast to results of earlier investigations the influence of thyroxine on CNS connectivity is not restricted to circum-metamorphic stages in frogs. Neuroanatomical findings in adult Xenopus treated with thyroxine reveal a spread of the ipsilateral retino-tectal projection. Sprouting fibers establish a tectal innervation pattern similar to the one found in primitive fish. The question arises, whether thyroxine also has morphogenetic effects in the mature CNS of other species.