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Correction: Ryan Murphy et al. Investigating the Effect of Wire Drawing and Heat Treatment on the Response of Ni<sub>50.9</sub>Ti<sub>49.1</sub> R-Phase Actuators. <i>Materials</i> 2025, <i>18</i>, 4931.

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Related Experiment Video

Updated: Mar 16, 2026

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

Xurography actuated valving for centrifugal flow control.

David J Kinahan¹, Philip L Early, Abhishek Vembadi

¹Biomedical Diagnostics Institute, Dublin City University, Glasnevin, Dublin 9, Ireland. david.kinahan@dcu.ie jens.ducree@dcu.ie.

|August 16, 2016

Summary

We developed a novel xurography-based valving system for centrifugal platforms, enabling automated liquid handling and assay protocols. This instrument-controlled scheme allows valve actuation even during disc rotation, enhancing centrifugal microfluidic applications.

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Published on: October 17, 2013

Area of Science:

Biomedical Engineering
Microfluidics
Analytical Chemistry

Background:

Centrifugal platforms offer advantages for automated assays but require precise fluid control.
Existing flow control mechanisms often lack integration flexibility or real-time actuation capabilities.
Xurography provides a method for fabricating microfluidic devices, but its application in dynamic flow control is limited.

Purpose of the Study:

To introduce a novel instrument-controlled valving scheme for centrifugal platforms utilizing xurography.
To demonstrate the feasibility of valve actuation during disc rotation for automated liquid handling.
To showcase the application of this technology in automating a biplex liver assay panel.

Main Methods:

A pneumatic valving system was designed using xurography, incorporating dissolvable films (DF) and pierceable membranes.
Valves were actuated by releasing trapped gas via a robotic knife-cutter or through selective venting under pneumatic pressure/suction.
A disc architecture was developed to automate liquid handling for a biplex liver assay, with valve actuation demonstrated during rotation and static states.

Main Results:

Successful valve actuation was demonstrated using dyed water during disc rotation via a robotic arm.
The xurography-based valving scheme enabled automated liquid handling for a biplex liver assay panel.
The system proved capable of actuating valves both during disc rotation and when the disc was stopped.

Conclusions:

The developed xurography-based valving scheme offers a versatile and instrument-controlled approach for fluid management on centrifugal platforms.
This technology facilitates automated assay protocols, including complex liquid handling steps, with potential for real-time actuation.
The successful demonstration in a biplex liver assay highlights the system's potential for advancing automated diagnostics and high-throughput screening.