Related Experiment Video
Updated: Mar 16, 2026
Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
Published on: November 6, 2018
The effect of chitosan-based gel on second degree burn wounds
S Honardar1, S S Kordestani1,2, M Daliri3
1Biomaterial Group, Medical Engineering Department, Amirkabir University of Technology, Tehran, Iran.
Objective:
Chitosan has been widely used in wound healing, including burn wounds. ChitoHeal gel, a novel chitosan-based gel, is studied to assess the effectiveness and rate of wound healing in second degree burns compared with traditional wound dressings.
Method:
New Zealand rabbits were divided into two groups, control and treatment. Second degree burn wounds were created using a hot round aluminium stamp. It was heated up to 80°C and applied 14 seconds without additional pressure. Morphological, histological, and molecular parameters were used to evaluate the effects of the chitosan-based gel on burn healing.
Results:
The study exhibited that in the control group with an increase in the number of keratinocytes due to the papillary growth of the epidermis, melanocyte pigmentation increased, and some melanin was observed in the dermis. In the treatment group, however, there was no hyper pigmentation nor overgrowth of the epidermis. Transmission electron microscopy micrographs of healed epidermis in treatment group showed melanocyte with normal morphology.
Conclusion:
The result of the present study is likely to be important for the development of novel strategies for wound healing using chitosan gel.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
01:22Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...