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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Starch nanocrystals based hydrogel: Construction, characterizations and transdermal application.

Haja Bava Bakrudeen1, C Sudarvizhi1, B S R Reddy1

  • 1Industrial Chemistry Laboratory, Central Leather Research Institute (CSIR-CLRI), Adyar, Chennai 600 020, India.

Materials Science & Engineering. C, Materials for Biological Applications
|August 16, 2016
PubMed
Summary

Researchers developed novel bio-nanocomposites using starch nanocrystals (SNCs) for transdermal drug delivery. These SNCs, derived from native starches, enhance hydrogel formulations for effective drug dispersion and controlled release.

Keywords:
AcyclovirDrug deliveryHydrogelsStarch nanocrystalsTransdermal

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Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Starch nanocrystals (SNCs) are gaining attention for bio-nanocomposite development.
  • Bio-based materials offer sustainable alternatives in various applications.

Purpose of the Study:

  • To prepare and characterize starch nanocrystals (SNCs) from native starches using different acids.
  • To utilize SNCs as filler materials in hydrogel formulations for transdermal drug delivery.
  • To evaluate the efficacy of SNC-based hydrogels for drug dispersion and permeation.

Main Methods:

  • Acid hydrolysis of native starches (using HCl and trifluoroacetic acid) to obtain SNCs.
  • Characterization of SNCs using TEM, SEM, particle size analysis, zeta potential, TG-DSC, and XRD.
  • Formulation of hydrogels with SNCs and an antiviral drug, followed by FT-IR analysis.
  • In vitro permeation studies using Franz diffusion cells.

Main Results:

  • Prepared SNCs exhibited high crystallinity and platelet morphology.
  • SNCs demonstrated good thermal stability and crystalline properties.
  • Physiochemical compatibility between the drug and SNCs in hydrogels was confirmed.
  • In vitro studies showed promising results for transdermal drug delivery using SNC-based hydrogels.

Conclusions:

  • Starch nanocrystals are effective filler materials for bio-nanocomposites.
  • SNC-based hydrogels facilitate successful transdermal drug delivery.
  • This approach offers a viable strategy for developing advanced drug delivery systems.