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Published on: January 24, 2025
Polysaccharide based nanogels in the drug delivery system: Application as the carrier of pharmaceutical agents
Tilahun Ayane Debele1, Shewaye Lakew Mekuria1, Hsieh-Chih Tsai1
1Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, postcode 106 Taipei, Taiwan.
Abstract:
Polysaccharide-based nanoparticles have fascinated attention as a vesicle of different pharmaceutical agents due to their unique multi-functional groups in addition to their physicochemical properties, including biocompatibility and biodegradability. The existence of multi-functional groups on the polysaccharide backbone permits facile chemical or biochemical modification to synthesize polysaccharide based nanoparticles with miscellaneous structures. Polysaccharide-based nanogels have high water content, large surface area for multivalent bioconjugation, tunable size, and interior network for the incorporation of different pharmaceutical agents. These unique properties offer great potential for the utilization of polysaccharide-based nanogels in the drug delivery systems. Hence, this review describes chemistry of certain common polysaccharides, several methodologies used to synthesize polysaccharide nanoparticles and primarily focused on the polysaccharide (or polysaccharide derivative) based nanogels as the carrier of pharmaceutical agents.
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