Bipolar Disorder and Population Health
Related Experiment Video
Updated: Mar 16, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Joseph M Cerimele1, John C Fortney1, Jürgen Unützer1
1The authors are with the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (e-mail: cerimele@uw.edu ).
Abstract:
This Open Forum addresses considerations for improving treatment of bipolar disorder. Most individuals with bipolar disorder report not receiving treatment from a psychiatrist in the past 12 months. In the United States, a large proportion of persons with bipolar disorder seek treatment in primary care. These patients have high symptom severity and functional impairment but are less likely to receive mood-stabilizing medications. In a prior study in a primary care setting, the authors found that one-third of patients with bipolar disorder improved after receiving treatment in primary care in a statewide collaborative care program. The collaborative care approach, originally developed for treating patients with depression in primary care, may need to be strengthened or adapted for treating patients with bipolar disorder. Strategies such as telehealth or enhanced collaborative care that also addresses psychosocial needs may be needed to effectively treat patients with bipolar disorder seeking treatment in primary care.
Related Concept Videos
Bipolar Disorder
Theoretical Approaches to Psychological Disorder
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Depressive Disorders: MDD and Dysthymia
Borderline Personality Disorder
Genetic and Environmental Contributions
Borderline Personality...
Models of Health Promotion and Illness Prevention II
The agent-host-environment model states that disease results...
Diagnostic and Statistical Manual of Mental Disorders (DSM)

