[Clinical approaches and factors affecting the results of fertilization in vitro in 1987]

In 1987 at the First Gynaecological and Obstetric Clinic in Brno a total of 314 stimulated cycle were monitored as part of the IVF and ET programme. 206 cycles (65.6%) were stimulated by means of clomiphene citrate and 108 cycles (34.4%) by a combination of clomiphene with hMG. Before aspiration 76 cycles (24.2%) were abolished, incl. 60 cycles because of inadequate stimulation. Aspiration of follicular fluid was made in 147 women by the laparoscopic route, in 91 women by transvaginal aspiration, using a vaginal ultrasonic probe. Of 238 aspirations of follicular fluid in 190 women at least one oocyte was obtained, a total of 412 oocytes, i. e. 1.73 +/- 1.4 oocyte per aspiration. A total of 146 oocytes were fertilized, i. e. 35.4% and an embryo transfer was made in 98 instances. In 1987 10 pregnancies were achieved, i. e. 10.2% pregnancies per one embryo transfer. Two preclinical abortions, four clinical abortions and four pregnancies were involved which terminated by the delivery of five healthy infants. The most important factor influencing the number of pregnancies after IVF and ET is the number of transferred embryos. 5.2%, 14.7% and 25% pregnancies per one to three transferred embryos were achieved. In order to make the results of different IVF and ET centres comparable, the authors recommend to classify the achieved pregnancies as the ratio of pregnancies per number of transferred embryos, stating the ratio of different groups. For the lay public the results per aspiration of follicular fluid should be published.