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Extended Spectrum Beta Lactamase producing Cephalosporin resistant Salmonella Typhi, reported from Rawalpindi,

Tehmina Munir1, Munir Lodhi2, Jawad Khaliq Ansari3

  • 1Department of Microbiology, Army Medical College, NUST, Rawalpindi, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|August 16, 2016
PubMed

Insights

Multidrug-resistant Salmonella Typhi is emerging, causing treatment failures even with third-generation cephalosporins. Carbapenems offer a successful treatment option for these complex typhoid fever cases.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Antimicrobial Resistance

Background:

  • Typhoid fever, caused by Salmonella Typhi, is prevalent in Southeast Asia.
  • Antibiotic resistance to first-line drugs and fluoroquinolones necessitates alternative treatments.
  • Third-generation cephalosporins are commonly used for empiric typhoid treatment.

Observation:

  • A case of typhoid fever resistant to third-generation cephalosporins and ciprofloxacin is presented.
  • The Salmonella Typhi strain exhibited multidrug resistance.
  • Standard antibiotic regimens proved ineffective for this patient.

Findings:

  • The Salmonella Typhi isolate demonstrated resistance to multiple antibiotics, including cephalosporins and fluoroquinolones.
  • Empiric treatment with a cephalosporin failed to resolve the infection.
  • Intravenous carbapenem administration led to successful treatment.

Implications:

  • Highlights the growing threat of multidrug-resistant typhoid.
  • Suggests carbapenems as a crucial alternative for treating resistant typhoid strains.
  • Emphasizes the need for continuous surveillance of antimicrobial resistance patterns in Salmonella Typhi.
Keywords:
Typhoid fever, Salmonella Typhi, cephalosporin, carbapenem.

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