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Cutaneous malakoplakia masquerading as pyoderma gangrenosum.

Mariam Smith-Pliego1, Jose Contreras-Ruiz1, Siobhan Ryan2

  • 1Department of Dermatology, "Dr. Manuel Gea Gonzalez" General Hospital, Mexico City, Mexico.

International Wound Journal
|August 16, 2016
PubMed
Summary

Cutaneous malakoplakia, a rare granulomatous disease, can affect the skin, particularly in immunocompromised individuals. This case highlights successful treatment of a chronic ulcer with cotrimoxazole.

Keywords:
Cutaneous malakoplakiaMichaelis-Gutmann bodiesPyoderma gangrenosumSkin ulcer

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Area of Science:

  • Dermatology
  • Pathology
  • Infectious Diseases

Background:

  • Cutaneous malakoplakia is a rare, infection-related granulomatous condition.
  • It is often linked to compromised immune systems.
  • Pathognomonic features include foamy macrophages with Michaelis-Gutman bodies.

Observation:

  • A case study of a 77-year-old male patient.
  • The patient presented with pyoderma gangrenosum.
  • A non-healing malleolar ulcer persisted for two years.

Findings:

  • The patient was diagnosed with cutaneous malakoplakia.
  • Successful treatment was achieved using cotrimoxazole.
  • This suggests cotrimoxazole as a potential therapeutic option.

Implications:

  • This case expands the understanding of cutaneous malakoplakia presentations.
  • It underscores the importance of considering malakoplakia in chronic non-healing ulcers.
  • Effective treatment with cotrimoxazole offers a therapeutic avenue for similar cases.