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Ion-Exchange Chromatography

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Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...

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Related Experiment Video

Updated: Mar 16, 2026

Photo-Induced Cross-Linking of Unmodified Proteins PICUP Applied to Amyloidogenic Peptides

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Polyion complex (PIC) particles: Preparation and biomedical applications.

Ignacio Insua¹, Andrew Wilkinson¹, Francisco Fernandez-Trillo¹

¹School of Chemistry, University of Birmingham, B15 2TT, UK.

European Polymer Journal

|August 16, 2016

Summary

This summary is machine-generated.

Oppositely charged polyions self-assemble into colloidal polyion complex (PIC) particles. These versatile nanomaterials show promise for nanomedicine and biosensing applications due to their tunable properties.

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Assembly and Characterization of Polyelectrolyte Complex Micelles

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Published on: March 2, 2020

Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Oppositely charged polyions spontaneously form colloidal polyion complex (PIC) particles in solution.
These PIC particles can encapsulate charged molecules, including therapeutics and probes.
PIC nanoparticles offer potential for advanced nanomedicine and chemical sensing.

Purpose of the Study:

To comprehensively discuss factors influencing PIC particle self-assembly.
To explore the response of PIC particles to various physical and chemical stimuli.
To highlight biomedical applications of PIC nanoparticles through key examples.

Main Methods:

Review of self-assembly principles for polyion complex formation.
Analysis of stimuli-responsive behavior of PIC nanoparticles.
Case study analysis of existing polyionic nanoparticle applications in medicine.

Main Results:

Identified key factors governing PIC particle formation and stability.
Demonstrated the tunable response of PIC particles to environmental changes.
Showcased successful applications in drug delivery and disease marker detection.

Conclusions:

PIC particles represent a promising platform for developing novel nanomedicines.
Their adaptability makes them suitable for sensitive chemical sensors.
Further research into PIC nanoparticles will advance biomedical technologies.