Related Experiment Video
Updated: Mar 16, 2026
Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
Published on: February 3, 2023
Integrated control of brown adipose tissue
Emanuele Marzetti1, Emanuela D'Angelo1, Giulia Savera1
1Department of Geriatrics, Neurosciences and Orthopedics, Teaching Hospital "Agostino Gemelli", Rome, Italy.
Brown adipose tissue (BAT) and beige/brite cells generate heat, offering potential for obesity and metabolic disease treatment. Understanding their complex regulation is key to developing effective therapies targeting these thermogenic tissues.
Area of Science:
- Metabolic physiology
- Adipose tissue biology
- Thermoregulation
Background:
- Brown adipose tissue (BAT) is a thermogenic organ crucial for heat production in mammals.
- Metabolically active BAT and beige/brite cells are found in adult humans, offering therapeutic potential.
- Thermogenic adipose tissues act as metabolic sinks for glucose and lipids.
Purpose of the Study:
- To review the regulation of brown and brite adipose tissue function.
- To discuss the therapeutic potential of targeting these tissues for metabolic disorders.
- To highlight the challenges in developing therapies due to complex interorgan regulation.
Main Methods:
- Literature review of current knowledge on BAT and brite cell regulation.
- Analysis of the role of thermogenic adipose tissue in energy metabolism.
- Discussion of therapeutic strategies targeting adipose tissue.
Main Results:
- BAT and beige/brite cells dissipate metabolic energy as heat.
- These tissues play a significant role in glucose and lipid metabolism.
- Complex interorgan networks regulate BAT and brite tissue mass and function.
Conclusions:
- Targeting BAT and brite adipose tissues holds promise for treating obesity and metabolic diseases.
- Further research into the intricate regulatory networks is essential for therapeutic development.
- Understanding the function and regulation of thermogenic adipocytes is critical for metabolic health interventions.
More Related Videos
09:21Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
Published on: February 18, 2015
07:22Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
Published on: March 28, 2013
Related Concept Videos
01:26Thermoregulation
01:23Physiological Control of Respiration
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...