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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
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Related Experiment Video

Updated: Mar 16, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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GENE PROFILING: IMPLICATIONS IN DERMATOLOGY.

Miroslav Blumenberg1, Marjana Tomic-Canic2

  • 1Departments of Dermatology and Biochemistry, and the NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY, 10016 USA, 212 263-5924.

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Summary

DNA microarrays analyze gene expression in human skin, revealing disease profiles for conditions like UV damage and cancer. Advances promise better diagnosis and treatment for skin disorders.

Keywords:
DNA microarraysUV lightcytokinesmelanomapsoriasistranscriptional profiling

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Area of Science:

  • Genomics
  • Dermatology
  • Molecular Biology

Background:

  • DNA microarrays allow comprehensive gene expression profiling in human tissues.
  • The skin, comprising epidermis and dermis, is a key research subject due to its accessibility.
  • Aberrant gene expression is linked to various skin diseases, including UV damage, inflammation, and cancers.

Purpose of the Study:

  • To investigate the application of DNA microarrays in understanding skin diseases.
  • To highlight the potential of gene expression analysis in dermatology.

Main Methods:

  • Utilizing DNA microarrays to measure the expression levels of numerous genes simultaneously.
  • Analyzing gene expression profiles in skin tissues (epidermis and dermis).

Main Results:

  • DNA microarrays have successfully identified aberrant gene expression profiles in various skin conditions.
  • Extensive research has been conducted on both epidermal and dermal gene expression.

Conclusions:

  • DNA microarray technology is valuable for characterizing gene expression in skin diseases.
  • The decreasing cost and development of bedside applications for DNA arrays offer significant potential for advancing dermatologic diagnosis, treatment, and prevention.