Related Experiment Video
Updated: Mar 16, 2026

Establishment of Acute Pontine Infarction in Rats by Electrical Stimulation
Published on: August 27, 2020
"Salt and Pepper" Pontine Infarct.
Lance J Lyons1, Susan W Law, John L Kubie
1SUNY Downstate College of Medicine (LJL), Brooklyn, New York; Department of Neurology and Stroke Center (SWL), SUNY Downstate Medical Center, Brooklyn, New York; Department of Cell Biology (JLK), SUNY Downstate Medical Center, Brooklyn, New York.
A paramedian pontine stroke can cause unique "salt and pepper" eye pain. Recognizing this rare stroke symptom is crucial for timely diagnosis and preventing poor clinical outcomes.
Area of Science:
- Neurology
- Ophthalmology
Background:
- Brainstem strokes, specifically in the paramedian pontine region, can manifest with unusual neurological symptoms.
- Understanding the diverse clinical presentations of stroke is essential for accurate diagnosis.
Observation:
- Patients experiencing a paramedian pontine stroke may report a distinct sensation of eye pain, described as "salt and pepper" or "pepper rubbed into the eye."
- This specific type of eye pain is an uncommon but notable symptom associated with this type of stroke.
Findings:
- While the localization of brain lesions in reported cases is consistent, the precise mechanism causing this unique eye pain remains unclear.
- The symptom highlights a potential link between pontine lesions and ocular sensory disturbances.
Implications:
- Clinicians must be aware of this rare stroke presentation to avoid diagnostic delays.
- Early identification of paramedian pontine stroke presenting with eye pain can significantly improve patient outcomes and management strategies.
Related Concept Videos
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Olfactory Receptors: Location and Structure

