Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PMTNet: A Part-Centric Missing-Aware Temporal Network for Cat Behavior Recognition in Unconstrained Videos.

Animals : an open access journal from MDPI·2026
Same author

Long-term sero-epidemiological trends of Nine respiratory pathogens in a predominantly pediatric population in Southwest China: a multicenter retrospective study (2019-2023).

BMC infectious diseases·2026
Same author

Coordination and π-π Stacking-Driven Conjugated Polymer Sensor Array for Polyphenol Fingerprinting and Tea Discrimination.

Analytical chemistry·2026
Same author

Pretargeted PROTAC Strategy Enables Precise Tumor Target Degradation <i>via</i> Self-Assembling Peptides.

ACS applied materials & interfaces·2026
Same author

Mechanically Adaptive Polyimide Interfaces for Stable High-Voltage NCM-Sulfide All-Solid-State Batteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Impact of kidney dysfunction on outcomes in peripheral artery disease: A multi-database cohort study.

iScience·2026

Related Experiment Video

Updated: Mar 16, 2026

Synthesis of an In vivo MRI-detectable Apoptosis Probe
06:58

Synthesis of an In vivo MRI-detectable Apoptosis Probe

Published on: July 31, 2012

9.6K

Conjugated Polyelectrolyte Nanoparticles for Apoptotic Cell Imaging.

Yu Liu1,2, Pan Wu1,2, Jianhua Jiang1

  • 1Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.

ACS Applied Materials & Interfaces
|August 16, 2016
PubMed
Summary
This summary is machine-generated.

New conjugated polyelectrolyte nanoparticles (CPNs) were developed for early apoptosis recognition. These PPET3/R8 CPNs effectively target and image apoptotic cells, showing potential for diagnostic applications.

Keywords:
apoptosiscell imagingconjugated polyelectrolytes (CPEs)conjugated polymer nanoparticles (CPNs)self-assemble

More Related Videos

Monitoring Cleaved Caspase-3 Activity and Apoptosis of Immortalized Oligodendroglial Cells using Live-cell Imaging and Cleaveable Fluorogenic-dye Substrates Following Potassium-induced Membrane Depola
10:45

Monitoring Cleaved Caspase-3 Activity and Apoptosis of Immortalized Oligodendroglial Cells using Live-cell Imaging and Cleaveable Fluorogenic-dye Substrates Following Potassium-induced Membrane Depola

Published on: January 13, 2012

16.5K
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

9.0K

Related Experiment Videos

Last Updated: Mar 16, 2026

Synthesis of an In vivo MRI-detectable Apoptosis Probe
06:58

Synthesis of an In vivo MRI-detectable Apoptosis Probe

Published on: July 31, 2012

9.6K
Monitoring Cleaved Caspase-3 Activity and Apoptosis of Immortalized Oligodendroglial Cells using Live-cell Imaging and Cleaveable Fluorogenic-dye Substrates Following Potassium-induced Membrane Depola
10:45

Monitoring Cleaved Caspase-3 Activity and Apoptosis of Immortalized Oligodendroglial Cells using Live-cell Imaging and Cleaveable Fluorogenic-dye Substrates Following Potassium-induced Membrane Depola

Published on: January 13, 2012

16.5K
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

9.0K

Area of Science:

  • Materials Science
  • Biotechnology
  • Cell Biology

Background:

  • Conjugated polyelectrolytes (CPEs) are advanced materials with tunable optical properties.
  • Developing targeted imaging agents for early disease detection is crucial.

Purpose of the Study:

  • To design and synthesize novel anionic CPEs for nanoparticle construction.
  • To evaluate the potential of these nanoparticles for imaging early apoptotic cells.

Main Methods:

  • Synthesis of poly(p-phenylene ethynylene thiophene) based CPEs, including PPET3-CO2Na.
  • Self-assembly of PPET3-CO2Na with octaarginine (R8) peptide to form CPE-based nanoparticles (CPNs).
  • Cell imaging studies using apoptotic and normal cells, with colocalization analysis.

Main Results:

  • PPET3-CO2Na exhibited enhanced optical properties compared to PPE-CO2Na.
  • PPET3/R8 CPNs self-assembled effectively via electrostatic interactions.
  • CPNs showed selective colocalization with apoptotic cells, targeting early apoptosis markers.

Conclusions:

  • Novel PPET3/R8 CPNs are effective for selective cell imaging of early apoptosis.
  • The developed nanoparticles demonstrate potential for early apoptosis recognition in cell imaging applications.