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Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three
Olivia Febvey1, Joachim Schüz, Helen D Bailey
1International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon (Febvey, Drs Schüz, Bailey, Olsson); Institut National de la Santé (INSERM) U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif (Drs Bailey, Clavel, Lacour, Orsi); Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS) (Drs Bailey, Clavel, Lacour, Orsi); RNCE - National Registry of Childhood Cancers, Villejuif (Dr Clavel); RNCE - National Registry of Childhood Cancers, Nancy, France (Dr Lacour); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, UK (Drs Lightfoot, Roman); Institute for Risk Assessment Sciences (IRAS), Department of Environmental Epidemiology, Utrecht University (Drs Vermeulen, Kromhout); Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (Dr Vermeulen); and The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (Dr Olsson).
Objective:
The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure.
Methods:
We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs).
Results:
The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% CI: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% CI: 0.53 to 0.95).
Conclusion:
Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors.
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