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Peripheral vascular disease. Rheologic variables during controlled ischemia.
G Ciuffetti1, M Mercuri, E Mannarino
1Istituto di Clinica Medica II, University of Perugia, Italy.
Circulation
|August 1, 1989
Summary
Peripheral vascular disease patients exhibit altered blood viscosity and white blood cell counts. Mononuclear leukocyte filterability may serve as a key functional marker for this condition.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Biophysics
Background:
- Peripheral vascular disease (PVD) affects blood flow, impacting hemorheologic factors.
- Understanding rheological changes is crucial for identifying disease markers.
Purpose of the Study:
- To identify functional rheologic markers for peripheral vascular disease.
- To compare hemorheologic behavior at rest and after exercise in PVD patients versus healthy controls.
Main Methods:
- Studied hemorheologic factors (blood viscosity, fibrinogen, white blood cell count, mononuclear leukocyte filterability) at rest and post-treadmill exercise.
- Compared 30 male PVD patients (Stage II) with 20 healthy controls.
Main Results:
- At rest, PVD patients showed significantly higher whole blood viscosity, fibrinogen levels, and white blood cell counts.
- Post-exercise, mononuclear leukocyte filterability significantly varied in PVD patients and improved during recovery.
Conclusions:
- Mononuclear leukocyte filterability demonstrates a potential link to exercise-induced ischemia in PVD.
- Mononuclear filterability emerges as a promising functional rheologic marker for peripheral vascular disease.