Related Experiment Video
Updated: Mar 16, 2026
11:15
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
25.2K
Synchronous Multiple Lung Adenocarcinomas: Estrogen Concentration in Peripheral Lung
Koei Ikeda1, Kenji Shiraishi1, Ayaka Yoshida1
1Departments of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
Plos One
|August 16, 2016
Summary
Elevated estrogen levels in peripheral lung tissue are linked to synchronous multiple lung adenocarcinomas (SMLA) in postmenopausal women. This suggests estrogen may drive multicentric lung cancer development.
Area of Science:
- Oncology
- Endocrinology
- Pulmonology
Background:
- Synchronous multiple lung adenocarcinomas (SMLA) detection is rising with advanced imaging.
- The origins of multicentric adenocarcinoma development remain unclear.
- This study investigates estrogen's role in SMLA.
Purpose of the Study:
- To quantify peripheral lung estrogen concentrations in postmenopausal women with SMLA.
- To explore the relationship between estrogen levels, genetic factors, and SMLA.
Main Methods:
- Measured estrone (E1) and estradiol (E2) tissue concentrations in noncancerous lung tissue using liquid chromatography/electrospray tandem mass spectrometry.
- Quantified CYP19A1 mRNA expression via real-time PCR.
- Analyzed 30 SMLA patients and 79 control patients with single lung adenocarcinoma.
Main Results:
- E1 and E2 concentrations were significantly higher in SMLA cases compared to controls.
- The minor allele (A) of SNP rs3764221 correlated with increased E1/E2 levels and higher CYP19A1 mRNA expression.
Conclusions:
- Peripheral lung tissue exhibits higher estrogen concentrations in SMLA patients.
- Elevated estrogen may contribute to the multicentric development of lung adenocarcinomas.
