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Published on: January 19, 2022
Mean Platelet Volume as a Potential Predictor of Cholesteatoma in Children
Mehmet Akif Eryilmaz1, Serhan Derin
1*Otorhinolaryngology Department, Meram Medical Faculty, Necmettin Erbakan Univerisity, Konya †Otorhinolaryngology Department, Mugla Sitki Kocman University, School of Medicine, Mugla, Turkey.
Insights
Mean platelet volume (MPV) may predict childhood cholesteatoma. Lower MPV levels in children with cholesteatoma suggest its utility as a reliable, inexpensive diagnostic marker for this chronic inflammatory condition.
Area of Science:
- Otolaryngology
- Pediatric Medicine
- Inflammatory Disorders
Background:
- Cholesteatoma is a destructive inflammatory condition of the middle ear, potentially causing hearing loss and complications.
- Mean platelet volume (MPV) is recognized as a prothrombotic and proinflammatory marker.
Purpose of the Study:
- To evaluate the predictive value of MPV and other hematological parameters for diagnosing cholesteatoma in pediatric chronic otitis media.
- To compare these markers between cholesteatomatous, noncholesteatomatous, and healthy pediatric groups.
Main Methods:
- Retrospective analysis of 24 patients with cholesteatomatous chronic otitis media, 9 with noncholesteatomatous chronic otitis media, and 36 healthy controls.
- Comparison of white blood cell count, MPV, erythrocyte distribution width, neutrophil-to-lymphocyte ratio, and platelet lymphocyte ratio among the groups.
Main Results:
- Mean platelet volume (MPV) was significantly lower in the cholesteatoma group (8.17 fL) versus controls (10.42 fL) (P < 0.001).
- An MPV cutoff of 9.5 fL demonstrated high sensitivity (86%) and specificity (84%) for predicting cholesteatoma.
- Other studied parameters showed no significant differences between cholesteatomatous and noncholesteatomatous groups.
Conclusions:
- Mean platelet volume (MPV) shows potential as a rapid, reliable, and cost-effective marker for identifying cholesteatoma in children.
- MPV's predictive capability offers a valuable tool for the early diagnosis of cholesteatoma in pediatric patients.
Objectives:
Cholesteatoma is a chronic inflammatory clinical disorder, and it may cause hearing loss and various complications due to its destructive nature. Mean platelet volume (MPV) is a prothrombotic and proinflammatory marker. The aim of this study is to investigate predictive values of MPV, neutrophil-to-lymphocyte ratio, erythrocyte distribution width, and platelet lymphocyte ratio in cholesteatomatous or noncholesteatomatous pediatric chronic otitis media.
Methods:
In this study, the authors retrospectively analyzed 24 patients with cholesteatomatous chronic otitis media, 9 patients with noncholesteatomatous chronic otitis media, and 36 age- and sex-matched healthy controls. Cholesteatomatous and noncholesteatomatous chronic otitis media groups were compared with each other, and with controls for WBC, MPV, erythrocyte distribution width, neutrophil-to-lymphocyte ratio, and platelet lymphocyte ratio.
Results:
Mean platelet volume was significantly lower in patients with cholesteatoma (8.17 ± 1.22 fL) compared with the control group (10.42 ± 0.87 fL) (P <0.001). Region of conversion curve analysis showed that the cutoff level of 9.5 fL for MPV was an independent predictor for cholesteatoma with a high sensitivity (86%) and specificity (84%). Cholesteatomatous and noncholesteatomous chronic otitis media patients were similar for other parameters studied.
Conclusion:
Mean platelet volume may be used as a fast-to-obtain, reliable, and inexpensive marker with a high predictive level to indicate cholesteatoma in children.
