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Decoding intravesical pressure from local field potentials in rat lumbosacral spinal cord
Changkyun Im1, Hae Yong Park, Chin Su Koh
1Department of Biomedical Engineering, College of Health Science, Yonsei University, Wonju 26493, Korea. BK21 Plus Transformative Training Program for Creative Mechanical Engineers, Seoul National University, Seoul 08826, Korea.
Journal of Neural Engineering
|August 16, 2016
Summary
Monitoring intravesical pressure is crucial for bladder health. High-frequency local field potential (LFP) activity from the spinal cord offers a robust alternative to spike signals for tracking bladder pressure.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Urology
Background:
- Chronic intravesical pressure monitoring is essential for managing bladder conditions like hypertension.
- Current methods using neural spike activity face challenges with signal acquisition due to electrode sensitivity and neurodegeneration.
- Local field potential (LFP) recordings show greater resilience to electrode placement changes and tissue reactions.
Purpose of the Study:
- To investigate if local field potential (LFP) signals from the lumbosacral dorsal horn can effectively monitor intravesical pressure.
- To compare the efficacy of LFP signals with traditional spike activity for intravesical pressure decoding.
Main Methods:
- Simultaneous recording of LFP and spike activities from the lumbosacral spinal cord in anesthetized rats.
- Bladder filling was performed during recordings to simulate physiological conditions.
- Analysis of LFP power spectrum, particularly in high-frequency bands, for correlation with intravesical pressure.
Main Results:
- LFP activities were found to contain significant information regarding intravesical pressure, comparable to spike activities.
- Intravesical pressure was successfully decoded from the power of high-frequency LFP bands (83.9-256 Hz).
- Decoding performance using high-frequency LFP was similar to that achieved with spike train analysis.
Conclusions:
- High-frequency LFP activity serves as a viable alternative signal for monitoring intravesical pressure.
- This finding supports the development of closed-loop systems for improved urinary control.
- LFP offers a more stable and potentially more reliable method for long-term bladder pressure monitoring.
