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Updated: Mar 16, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Regulatory circuits of T cell function in cancer
Daniel E Speiser1,2, Ping-Chih Ho1, Grégory Verdeil1
1Department of Oncology, Ludwig Cancer Research, University of Lausanne, Biopole 3 - 02DB92, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.
Abstract:
Recent progress in cancer immunotherapy emphasizes the importance of understanding immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to mechanisms that are evolutionarily conserved or acquired by somatic mutations. The dysfunctional state of T cells has been termed 'exhaustion', on the basis of similarities to dysfunctional T cells in chronic infections. However, despite shared properties, recent studies have identified marked differences between T cell dysfunction in cancer and chronic infection. In this Review, we discuss T cell-intrinsic molecular alterations and metabolic communication in the tumour microenvironment. Identification of the underlying molecular drivers of T cell dysfunction is essential for the continued progress of cancer research and therapy.
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