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Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...

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Related Experiment Video

Updated: Mar 16, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Urticaria multiforme: Two cases with histopathological findings

Luciana P Samorano¹, Vanessa V Fernandez¹, Neusa Y S Valente¹

¹Department of Dermatology, Hospital das Clínicas of the University of São Paulo Medical School, São Paulo, Brazil.

Allergology International : Official Journal of the Japanese Society of Allergology

|August 17, 2016

Summary

No abstract available in PubMed .

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