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Updated: Mar 16, 2026
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
20.8K
Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis
Sung-Young Shin1,2, Lan K Nguyen3,4
1Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton Victoria 3800, Australia. sungyoung.shin@monash.edu.
Genes
|August 17, 2016
Summary
The Hippo signalling pathway interacts with ERK and Akt pathways to control cell growth. Mathematical modeling reveals complex crosstalk mechanisms driving diverse cellular responses in disease.
Area of Science:
- Cellular signalling pathways
- Molecular biology
- Systems biology
Background:
- The Hippo signalling pathway regulates cell apoptosis and proliferation, impacting human diseases.
- It involves MST1/2 and LATS1/2 kinases and interacts with Akt and ERK MAPK pathways.
- Complex regulatory mechanisms, including protein interactions and feedback loops, govern pathway crosstalk.
Purpose of the Study:
- To investigate the interplay of mechanisms within the Hippo-ERK signalling network.
- To understand how these interactions drive context-specific network dynamics.
- To provide a mechanistic explanation for observed signalling patterns.
Main Methods:
- Mathematical modelling
- Computational analysis
- Systematic analysis of network dynamics
Main Results:
- The Hippo-ERK network generates diverse dynamical profiles and dose-response patterns.
- Akt exhibits opposing, dose-dependent functions towards ERK via specific protein interactions and feedback.
- Ras plays a multi-functional role, inducing biphasic MST2 and ERK responses through competitive protein interactions.
Conclusions:
- This study offers the first in-depth analysis of Hippo-ERK network dynamics.
- Mechanistic explanations for diverse signalling patterns were identified.
- Findings provide a foundation for future research on Hippo pathway crosstalk and disease.
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