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Tiaprofenic acid induced photosensitivity
R A Neumann1, R M Knobler, H Lindemayr
1Department of Dermatology II, University of Vienna, Austria.
Contact Dermatitis
|April 1, 1989
Summary
Photopatch testing revealed that over half of patients experienced phototoxic reactions to tiaprofenic acid. Reaction severity was consistent regardless of UVA light intensity, suggesting a high sensitivity to this non-steroidal anti-inflammatory drug.
Area of Science:
- Dermatology
- Photobiology
- Pharmacology
Background:
- Tiaprofenic acid is a non-steroidal anti-inflammatory drug (NSAID).
- NSAIDs can cause photosensitivity reactions.
- Photopatch testing is a standard method for diagnosing photoallergic and phototoxic reactions.
Purpose of the Study:
- To evaluate the phototoxic potential of tiaprofenic acid.
- To determine the rate of phototoxic reactions to tiaprofenic acid in patients with suspected photosensitivity.
Main Methods:
- Photopatch testing was performed on 45 patients with suspected photosensitivity.
- Patients were exposed to tiaprofenic acid and UVA irradiation from two sources with different energy outputs.
- Reactions were assessed 0.5 to 48 hours post-irradiation.
Main Results:
- Phototoxic reactions to tiaprofenic acid were observed in 23 out of 45 patients (51%).
- The intensity and duration of reactions were similar despite variations in UVA light energy.
- No prior exposure to tiaprofenic acid was reported by any patient.
Conclusions:
- Tiaprofenic acid frequently causes phototoxic reactions.
- The phototoxic reaction to tiaprofenic acid is independent of UVA light intensity within the tested range.
- Patients presenting with photosensitivity should be evaluated for potential reactions to tiaprofenic acid.