Testing a purified lanolin preparation by a randomized procedure

Patients with a previous contact allergy to lanolin (wool alcohols and/or Amerchol L 101) were patch tested 1 to 4 years later with lanolin allergens, as well as purified anhydrous lanolin contained in a commercial cream. At this retest, only 20 out of 33 patients with a previous contact allergy to lanolin reacted to lanolin allergens, and only 1 to the purified lanolin (as is). None reacted to the commercial cream containing 6% purified lanolin, this being ascertained by patch test as well as by usage test. To avoid bias at reading, patch tests were applied in a randomized computer-based order and read blindly.