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Updated: Mar 16, 2026
Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
Microsporidial stromal keratitis and endophthalmitis in an immunocompetent patient
Arjun B Sood1,2, Matthew R Debiec3, Steven Yeh4,5
1Department of Ophthalmology, Emory University, Atlanta, GA, USA. arjunbsood@gmail.com.
Purpose:
The purpose of this study is to report a case of microsporidial endophthalmitis after penetrating keratoplasty in a healthy patient and discuss the management.
Methods:
This is a case report.
Results:
A 69-year-old healthy male underwent penetrating keratoplasty for corneal scar secondary to herpes stromal keratitis. He presented with features of acute graft rejection 3 years later. After failure of medical management, a repeat full thickness keratoplasty was performed. Pathologic examination of the corneal specimen showed microsporidia. The patient then developed a chronic endophthalmitis, and a vitreous tap and injection followed by pars plana vitrectomy were performed. Pathologic examination of tissue showed microsporidia.
Conclusions:
Microsporidia are being increasingly identified as the cause of stromal keratitis. This is the first report of microsporidial endophthalmitis in a patient without underlying systemic illness.
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