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Cholinergic agonist reverses H1-induced memory deficit in mice
C E M Fernandes1, K R Serafim1, A C L Gianlorenço1
1Laboratory of Neuroscience, Physiotherapy Department, Center of Biological Sciences and Health, Federal University of Sao Carlos, Rod. Washington Luis, Km 235, 13565-905 Sao Carlos, Brazil.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|August 17, 2016
Summary
Nicotinic cholinergic agonist PNU-282987 did not affect anxiety or memory alone. However, it reversed chlorpheniramine-induced amnesia, suggesting a cholinergic-histaminergic interaction in mice.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- The amygdala plays a crucial role in emotional memory processing.
- Cholinergic and histaminergic systems are implicated in memory formation and retrieval.
- Understanding these systems' interactions is key to addressing memory deficits.
Purpose of the Study:
- To investigate the effects of PNU-282987, a nicotinic agonist, on anxiety and amnesia in mice.
- To explore the potential reversal of chlorpheniramine (CPA)-induced amnesia by PNU-282987.
- To examine the interaction between cholinergic and histaminergic systems in emotional memory.
Main Methods:
- Bilateral intraamygdalar microinjections of PNU-282987 and CPA in adult male Swiss mice.
- Utilized the elevated plusmaze (EPM) behavioral test.
- Statistical analysis using ANOVA to determine significance (p<0.05).
Main Results:
- Isolated intraamygdalar PNU-282987 did not alter anxiety or emotional memory.
- Combined PNU-282987 and CPA microinjections reversed CPA-induced memory deficits.
- No significant effects on anxiety were observed with PNU-282987 alone.
Conclusions:
- Intraamygdalar PNU-282987 does not induce anxiety or affect emotional memory independently.
- PNU-282987, in conjunction with CPA, can reverse amnesia, indicating a functional interaction.
- These findings suggest a role for cholinergic-histaminergic system interplay in modulating emotional memory acquisition in mice.
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