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Disease activity and lifestyle influence comorbidities and cardiovascular events in patients with acromegaly

Chiara Sardella1, Daniele Cappellani1, Claudio Urbani1

  • 1Department of Clinical and Experimental MedicineSection of Endocrinology, University of Pisa, Pisa, Italy.

European Journal of Endocrinology
|August 17, 2016
PubMed

Insights

Disease control and lifestyle choices significantly predict cardiovascular risks and comorbidities in acromegaly patients. Effective acromegaly management is key to reducing major adverse cardiovascular events (MACE).

Area of Science:

  • Endocrinology
  • Cardiology
  • Internal Medicine

Background:

  • Acromegaly, a condition of excess growth hormone, is associated with increased risks of comorbidities and cardiovascular events.
  • Identifying predictors for these complications is crucial for patient management.

Purpose of the Study:

  • To identify predictors of comorbidities (diabetes, hypertension) and major adverse cardiovascular events (MACE) post-acromegaly diagnosis.
  • To evaluate the impact of acromegaly treatment on these complications.

Main Methods:

  • Retrospective cohort study of 200 acromegaly patients.
  • Outcomes assessed: diabetes, hypertension, MACE.
  • Patients classified by treatment: post-adenomectomy (Hx), somatostatin analogue controlled (SSAc), or uncontrolled (SSAnc).
  • Cox regression analysis used for data evaluation.

Main Results:

  • Diabetes developed in 40.8% of patients; uncontrolled SSA (SSAnc) group showed higher risk (HR: 3.32).
  • Hypertension occurred in 35.5%; age and BMI were significant predictors.
  • MACE occurred in 11.8%; age and smoking were predictors.
  • Acromegaly therapy did not significantly influence hypertension or MACE rates.

Conclusions:

  • Disease control, regardless of treatment type, is a predictor of comorbidities and MACE in acromegaly.
  • Lifestyle factors, such as smoking, also play a significant role in cardiovascular risk.
Abstract

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