Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

12.0K
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
12.0K
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

283.7K
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
283.7K
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

25.1K
25.1K
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

15.9K
15.9K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

6.7K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
6.7K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

3.0K
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying intracellular mechanosensitive response upon spatially defined mechano-chemical triggering.

eLife·2026
Same author

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis.

Nature cell biology·2026
Same author

Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis.

Cell death & disease·2026
Same author

Establishment of an imaging-based screening pipeline for the identification of human ribosome biogenesis inhibitors.

BMC biology·2025
Same author

Proceedings of the 15<sup>th</sup> European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals.

mAbs·2025
Same author

Identification of coilin interactors reveals coordinated control of Cajal body number and structure.

The Journal of cell biology·2024

Related Experiment Video

Updated: Mar 16, 2026

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

8.8K

Cellular Reorganization during Mitotic Entry.

Lysie Champion1, Monika I Linder1, Ulrike Kutay1

  • 1Institute of Biochemistry, ETH Zurich, Otto-Stern-Weg 3, 8093 Zurich, Switzerland.

Trends in Cell Biology
|August 17, 2016
PubMed
Summary
This summary is machine-generated.

Eukaryotic cells undergo major architectural changes during early mitosis, involving cytoskeletal and organelle restructuring, to ensure accurate chromosome segregation and cell division. These processes are regulated by cell cycle kinases and are vital for cell fate.

Keywords:
Golgi fragmentation.actin cytoskeletoncell roundingmitochondrial fissionmitosisnuclear envelope breakdown

More Related Videos

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

10.8K
Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

15.1K

Related Experiment Videos

Last Updated: Mar 16, 2026

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

8.8K
Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

10.8K
Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

15.1K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Eukaryotic cell division (mitosis) requires significant cellular reorganization.
  • Cytoskeletal elements, chromatin, and organelles undergo drastic changes.
  • Proper chromosome segregation and organelle inheritance depend on these architectural alterations.

Purpose of the Study:

  • To provide an overview of major architectural changes during early mitosis.
  • To review recent progress in understanding the regulatory mechanisms of these changes.
  • To focus on mitotic cell rounding and organelle restructuring in mammalian cells.

Main Methods:

  • Literature review of recent scientific progress.
  • Analysis of cellular architectural changes during early mitosis.
  • Focus on regulatory mechanisms involving mitotic kinases.

Main Results:

  • Detailed overview of major architectural changes during early mitosis.
  • Identification of key regulatory mechanisms, particularly mitotic kinases.
  • Focus on cell rounding and organelle restructuring in mammalian cells.

Conclusions:

  • Mitotic entry involves tightly coordinated morphological alterations.
  • The fidelity of these architectural changes impacts mitotic progression and organismal homeostasis.
  • Understanding these processes is crucial for cell fate determination.