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Amoxycillin/clavulanic acid (Augmentin)-induced intrahepatic cholestasis
J F Dowsett1, T Gillow, A Heagerty
1Department of Gastroenterology, University College and Middlesex Hospital, Medical School, U.K.
Digestive Diseases and Sciences
|August 1, 1989
Abstract:
A 75-year-old man developed a biopsy-proven, drug-induced intrahepatic cholestasis after use of amoxycillin trihydrate combined with the beta-lactam inhibitor potassium clavulanate (Augmentin). Cholestatic liver injury is an uncommonly recognized, probably immunologically based adverse reaction to therapy with penicillin and its derivatives.