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Updated: Mar 16, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
Tyrosine Kinase Receptor Landscape in Lung Cancer: Therapeutical Implications
A Quintanal-Villalonga1, Luis Paz-Ares1, Irene Ferrer1
1Medical Oncology Department, Hospital Universitario Doce de Octubre, 28041 Madrid, Spain; Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Mardid, Spain.
Abstract:
Lung cancer is a heterogeneous disease responsible for the most cases of cancer-related deaths. The majority of patients are clinically diagnosed at advanced stages, with a poor survival rate. For this reason, the identification of oncodrivers and novel biomarkers is decisive for the future clinical management of this pathology. The rise of high throughput technologies popularly referred to as "omics" has accelerated the discovery of new biomarkers and drivers for this pathology. Within them, tyrosine kinase receptors (TKRs) have proven to be of importance as diagnostic, prognostic, and predictive tools and, due to their molecular nature, as therapeutic targets. Along this review, the role of TKRs in the different lung cancer histologies, research on improvement of anti-TKR therapy, and the current approaches to manage anti-TKR resistance will be discussed.
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