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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis IV01:26

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Peptic Ulcer Disease I: Introduction01:30

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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
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A Tuberculosis Molecular Bacterial Load Assay TB-MBLA
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Buruli ulcer in Malawi - a first report.

O O Komolafe1

  • 1Department of Microbiology, College of Medicine, P/Bag 360, Blantyre.

Malawi Medical Journal : the Journal of Medical Association of Malawi
|August 17, 2016
PubMed
Summary

Three acid-alcohol fast bacilli (AFB) were identified in chronic wound specimens. These slow-growing organisms, confirmed as Mycobacterium ulcerans, indicate the causative agent of Buruli ulcer disease.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Dermatology

Background:

  • Chronic wounds and ulcers are significant clinical challenges.
  • Identifying the etiological agents of chronic infections is crucial for effective treatment.
  • Mycobacterial infections, such as Buruli ulcer, require specific diagnostic approaches.

Purpose of the Study:

  • To identify acid-alcohol fast bacilli (AFB) in chronic wound/ulcer specimens.
  • To characterize the growth and biochemical properties of isolated AFB.
  • To confirm the presence of Mycobacterium ulcerans as the causative agent of Buruli ulcer.

Main Methods:

  • Specimens were collected from 161 patients with chronic wounds/ulcers over eight months.
  • Isolation and culture of AFB were performed on Lowenstein-Jensen (LJ) medium at 32°C.

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  • Biochemical tests, including catalase spot and heat stability tests, were conducted.

    • Main Results:

    • Three AFB organisms were isolated from the specimens.
    • The isolates exhibited slow growth, requiring 39-45 days for creamy-yellow colony formation on LJ medium.
    • All isolates tested positive for both catalase spot and catalase heat stability tests.

    Conclusions:

    • The isolated AFB were identified as Mycobacterium ulcerans based on their unique growth characteristics and biochemical profiles.
    • This study highlights the potential for Mycobacterium ulcerans to be present in chronic wounds/ulcers.
    • Early and accurate identification of Mycobacterium ulcerans is essential for managing Buruli ulcer disease.