Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation
Irina Lyadova Vladimirovna1, Ekaterina Sosunova1, Alexander Nikolaev1
1Central Tuberculosis Research Institute, Yauza Alley 2, Moscow 107564, Russia.
Abstract:
To protect host against immune-mediated damage, immune responses are tightly regulated. The regulation of immune responses is mediated by various populations of mature immune cells, such as T regulatory cells and B regulatory cells, but also by immature cells of different origins. In this review, we discuss regulatory properties and mechanisms whereby two distinct populations of immature cells, mesenchymal stem cells, and myeloid derived suppressor cells mediate immune regulation, focusing on their similarities, discrepancies, and potential clinical applications.
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