[THE PATHOGENESIS OF LUNG TUBERCULOMAS UNDER THE CONDITIONS OF A FAR NORTH REGION]
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Updated: Mar 16, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
Abstract:
The specific features of the pathogenesis of lung tuberculomas were studied in 302 patients among the indigenes and newcomers in the Far-North. The predominant formation of caseous foci from the tuberculous infiltrate located in the lung tissue in most cases was ascertained to be the specific feature of the development of lung tuberculomas under the conditions of a Far- North region, in Yakutia in particular. Tuberculoma formation shows a peculiar combination of evolving foci of acute specific pneumonia with a torpid inflammatory process, which contributes to the formation of multiple and large tuberculomas in the presence of significant pneumosclerosis. At the same time, homogeneous tuberculomas most commonly formed in both newcomers and indigenes.
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