Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.6K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

15.1K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
15.1K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

18.9K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
18.9K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

1.1K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.1K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

133.7K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
133.7K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

6.5K
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C(sp<sup>2</sup>)-Thio- and amino-methylated indole derivatives: one-pot synthesis, evaluation of cytotoxic and anti-inflammatory activity.

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agentsยท2026
Same author

[Pharmacological correction of endothelial dysfunction in patients with atherosclerotic lesions of peripheral arteries and diabetes mellitus (literature review)].

Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgeryยท2026
Same author

[The study of the behavioral reactions and duration of ultrasonic vocalization in rats from females stressed during pregnancy].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakovaยท2025
Same author

The role of the PPM1D gene in tumor pathogenesis.

Biomeditsinskaia khimiiaยท2025
Same author

Problems and prospects for finding new pharmacological agents among adenosine receptor agonists, antagonists, or their allosteric modulators for the treatment of cardiovascular diseases.

Biomeditsinskaia khimiiaยท2023
Same author

[Synergistic effects of GABA and hypoglycemic drugs].

Problemy endokrinologiiยท2023

Related Experiment Video

Updated: Mar 16, 2026

High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses
09:24

High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses

Published on: February 18, 2016

7.9K

[Glutamate Metabotropic Receptors: Structure, Localisation, Functions].

V N Perfilova, I N Tyurenkov

    Uspekhi Fiziologicheskikh Nauk
    |August 18, 2016
    PubMed
    Summary

    Metabotropic glutamate receptors (mGluRs) are crucial G-protein coupled receptors involved in neuronal and glial excitability. Their diverse functions and locations suggest potential therapeutic applications for neurological and mental health disorders.

    More Related Videos

    Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
    12:47

    Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

    Published on: March 20, 2014

    14.7K
    Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps
    09:30

    Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps

    Published on: July 19, 2024

    2.2K

    Related Experiment Videos

    Last Updated: Mar 16, 2026

    High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses
    09:24

    High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses

    Published on: February 18, 2016

    7.9K
    Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
    12:47

    Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

    Published on: March 20, 2014

    14.7K
    Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps
    09:30

    Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps

    Published on: July 19, 2024

    2.2K

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Pharmacology

    Context:

    • Metabotropic glutamate receptors (mGluRs) are a family of G-protein coupled receptors.
    • They are classified into three groups (I, II, III) with eight subtypes.
    • mGluRs modulate cellular excitability via IP3 and adenylate cyclase signaling pathways.

    Purpose:

    • To review the structure, location, and functions of mGluRs.
    • To explore the involvement of mGluRs in various physiological and pathological processes.
    • To discuss the therapeutic potential of mGluR modulators.

    Summary:

    • mGluRs are widely distributed in the central nervous system and peripheral non-neuronal tissues.
    • Dysregulation of mGluRs is implicated in neurodegenerative diseases, cognitive disorders, and autoimmune processes.
    • Agonists and antagonists targeting mGluRs are promising therapeutic agents for conditions like depression, anxiety, and Parkinson's disease.

    Impact:

    • Provides a comprehensive overview of mGluR biology and therapeutic relevance.
    • Highlights the potential of mGluR-based therapies for a range of CNS and non-CNS disorders.
    • Informs future research directions in the development of novel pharmacological treatments.