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Longitudinal imaging of the ageing mouse
E Dall'Ara1, M Boudiffa2, C Taylor3
1Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK; INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield, UK.
Mechanisms of Ageing and Development
|August 18, 2016
Summary
Non-invasive in vivo imaging techniques in mouse models allow longitudinal study of age-related diseases and treatment effects. This review details modalities like micro-CT, MRI, PET, SPECT, ultrasound, and optical imaging for aging research.
Area of Science:
- Preclinical research
- Biomedical imaging
- Aging studies
Background:
- Non-invasive in vivo imaging provides longitudinal, quantitative data on tissue and organ changes in mouse models.
- These techniques are crucial for evaluating phenotypic alterations due to diseases and treatments.
- Current applications for studying aging in mice using these modalities are not well-defined.
Purpose of the Study:
- To review the applications of common in vivo imaging modalities in mouse studies for aging research.
- To highlight how these techniques can assess age-related pathologies and treatment efficacy.
- To provide a comprehensive overview for researchers utilizing mouse models of aging.
Main Methods:
- Review of established in vivo imaging techniques in preclinical research.
- Focus on modalities applicable to longitudinal studies in mouse models.
- Inclusion of micro-computed-tomography, preclinical magnetic-resonance-imaging, preclinical positron-emission-tomography, preclinical single photon emission computed tomography, ultrasound, intravital microscopy, and whole body optical imaging.
Main Results:
- Most age-related pathologies in mice (e.g., osteoporosis, arthritis, diabetes, cancer, dementia) are amenable to in vivo imaging.
- Longitudinal imaging enables quantification of treatment effects before clinical trials.
- Non-invasive methods allow simultaneous assessment of multiple tissue/organ phenotypes over time in the same animal.
Conclusions:
- In vivo imaging modalities are valuable tools for investigating aging processes and related diseases in mouse models.
- These techniques facilitate the development and testing of novel therapeutic interventions for age-related conditions.
- Further exploration of these imaging modalities can enhance our understanding of aging and its associated dysfunctions.
